This test is used when sickle cell anemia (HbSS) or carriership of sickle cell trait (HbAS) is suspected. By analyzing the distribution of different hemoglobin types in the blood, the test can identify whether the sickle cell allele (S) is present, and to what extent.
What does the test show?
The analysis maps different hemoglobin fractions in the blood, in particular:
- Presence of HbS (sickle cell hemoglobin).
- Distribution between normal hemoglobin (HbA) and HbS – which determines whether you are a carrier (HbAS) or have the disease (HbSS).
If no HbS is detected, sickle cell can be ruled out, making this an effective first-line analysis.
Important to know
- In the event of suspected or positive findings of HbS, additional DNA analysis is needed.
- The DNA analysis requires new sampling and is not included in this test. It is paid for separately by the customer if it becomes necessary.
Preparations and limitations
- The sample should be taken before any blood transfusion. If a transfusion has occurred in the last 3 months, this must be stated and confirmed iron deficiency should, if possible, be addressed before suspected thalassemia is investigated.
- The test is not used in cases of suspected fetomaternal transfusion
