Vitamin B12 deficiency

Vitamin B12, cobalamin, is an essential nutrient that the body needs for the production of red blood cells, nerve function, and DNA synthesis. The body cannot manufacture vitamin B12 itself, so we need to add B12 through diet or supplementation.

Quick version

B12 is mainly found in foods such as meat, fish, dairy products and eggs. Some groups have a harder time getting B12 through their diet, such as vegans and vegetarians, and therefore often need to add a dietary supplement to meet the body's needs and avoid the risk of developing a B12 deficiency.

Common symptoms of B12 deficiency

A deficiency of vitamin B12 can develop gradually and is often not immediately noticeable at the beginning of the process. However, as the level of B12 in the body decreases, several different symptoms can occur. Here are some common signs and symptoms of B12 deficiency:

  • Fatigue and lack of energy
  • Shortness of breath with exertion
  • Headache
  • Heart palpitations
  • Pale or yellowish skin
  • Numbness or tingling in the hands and feet
  • Balance problems
  • Irritability, low mood or depression
  • Difficulty concentrating and memory problems
  • Red, smooth tongue or mouth ulcers

Some people also experience intestinal problems, such as diarrhea or loss of appetite.

B12 deficiency - risk groups

A common cause of B12 deficiency is that you get too little of the vitamin through food or because the body cannot absorb the vitamin properly. Factors that can cause difficulty absorbing B12 are:

  • You are older
  • You have a gastrointestinal disease such as celiac disease, gastritis or Crohn's disease
  • After gastric surgery
  • Long-term use of certain medications (e.g. metformin or antacids)
  • You have a strict vegetarian or vegan diet without supplements

Here you can learn more about how to how to help your body absorb more B12.

Consequences of long-term B12 deficiency

Both the nervous system and blood formation are affected if you have a B12 deficiency for a long time. Furthermore, this can lead to:

  • Megaloblastic anemia (a type of anemia with large, immature red blood cells)
  • Nerve damage that causes numbness, poor reflexes and impaired sensation
  • Psychological symptoms such as depression, confusion or dementia-like conditions

To reduce possible permanent nerve damage, it is important to detect and treat B12 deficiency in time.

How to know if you have a B12 deficiency

A blood test can show if you have low levels of vitamin B12. blood count (Hb), homocysteine and methylmalonate (MMA) are also often checked, which can be elevated in B12 deficiency even if the B12 level is within the reference range.


Written by: The team at Testmottagningen.se
Reviewed by:Elvira-Maria Vaida, leg. läkare

Related tests and health checks

Health check B12 deficiency

Health check B12 deficiency

Investigation of B12 deficiency
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Doctor's assessment included

Once your results are ready, a licensed doctor will review them alongside the health information you have provided. You'll receive a personalized written assessment to help you understand what your results mean for your health and whether there is anything you should be aware of or can do to improve your health.

What does the doctor's assessment include?

  • Overall assessment – a summary of your examination results and what they may indicate about your health.
  • Explanation of your results – what your blood test values or findings from an imaging examination mean.
  • Comments on abnormalities – what abnormal values or findings may indicate and whether further follow-up is needed.
  • Personalized recommendations – advice on how to improve or maintain your health and whether further medical follow-up is recommended.

What happens if something abnormal is found?

An abnormal result doesn't necessarily mean something is wrong. Your doctor will make an individual assessment and explain any abnormal values or findings in your written report.

If your results show significant abnormalities or require prompt follow-up, a doctor will also contact you by phone at no extra cost.

The assessment is based on your examination results and the health information you have provided. It does not replace a comprehensive medical examination.

  • Blood analysis for investigation of suspected B12 deficiency.
  • In-depth analysis to identify functional B12 deficiency.
  • Assessment of blood count and impact on red blood cells.
  • Recommendations for action and follow-up.

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