What is high-sensitivity CRP (hs-CRP)?
High-sensitivity CRP, also known as hs-CRP (high-sensitivity C-reactive protein), is a blood test that measures very low levels of the inflammation marker C-reactive protein in the blood. Unlike a standard CRP test, which is primarily used to detect acute infections, hs-CRP can identify low-grade inflammation – a subtle and often long-lasting type of inflammation that can be linked to lifestyle factors and an increased risk of cardiovascular disease.
Why test your hs-CRP?
A high-sensitivity CRP test is useful for getting a more detailed picture of your body's inflammation levels. It can help you:
- Detect low-grade inflammation – Long-term, low-grade inflammation can contribute to several chronic conditions and is influenced by factors such as stress, lack of sleep, diet, smoking, obesity and physical inactivity.
- Evaluate lifestyle changes – By comparing values over time, you can see how improved diet, exercise or reduced stress affect your body.
- Get early warning signs – Elevated hs-CRP levels can be an early marker of increased risk of cardiovascular disease or other inflammatory conditions, even before symptoms appear.
How is the test done?
The sample is taken through a venous blood sample performed by a healthcare professional. The analysis is performed in an accredited laboratory with very high precision to be able to measure even minimal amounts of CRP in the blood.
What can cause high levels of hs-CRP?
- Low-grade chronic inflammation – Common with prolonged stress, obesity, unhealthy diet or lack of physical activity.
- Acute inflammation – Temporary infections, injuries or severe inflammatory reactions often raise CRP levels significantly.
- Autoimmune and chronic diseases – Diseases such as rheumatoid arthritis, lupus or inflammatory bowel disease can cause persistently elevated values.
Interpretation of hs-CRP values
- <1 mg/L – Low level, indicates low inflammatory activity.
- 1–3 mg/L – Moderately elevated level, may indicate some inflammatory activity.
- >3 mg/L – Elevated level, indicates ongoing inflammation or increased risk of cardiovascular disease.
Note: CRP rises rapidly during temporary infections, such as colds or flu. To get a fair picture of low-grade inflammation, the sample should be taken when you are healthy and infection-free.
