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HTC

Holotranscobalamin

Holotranscobalamin, often abbreviated HTC, is the active form of vitamin B12 – the fraction that can be absorbed by the body’s cells. A holotranscobalamin test is used to detect early signs of B12 deficiency and to assess the body’s nutritional status.

HTC
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S-Holotranscobalamin

Active B12

279 kr139 kr

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Contents

What is holotranscobalamin?

Holotranscobalamin (HTC) is a specific fraction of vitamin B12 that is bound to a transport protein called transcobalamin II. With the help of this protein, the body’s cells can absorb and use the vitamin where it is needed. Only about 10–30% of all B12 in the blood exists as HTC, but it is this portion that the body can actually utilize.

The role of vitamin B12 in the body

Vitamin B12 is essential for the production of red blood cells, proper nerve function, and DNA synthesis. Low levels of B12 can lead to anemia, neurological problems, and reduced energy metabolism.

Identifying B12 deficiency using holotranscobalamin

HTC is considered a more sensitive marker than total B12 because it reflects the amount of active vitamin available in the blood. HTC levels often decrease before total B12 is affected, allowing for earlier detection of deficiency.

How is holotranscobalamin measured?

HTC levels can be measured through a blood test. The result is often interpreted together with other markers such as total B12, Methylmalonate (MMA) and Homocysteine to provide a more complete picture of vitamin status. Low HTC combined with elevated MMA confirms a deficiency of active B12 (HTC).

What can cause low holotranscobalamin levels?

Low holotranscobalamin levels are often an early sign of vitamin B12 deficiency. B12 deficiency is commonly caused by poor absorption, a vegetarian or vegan diet, atrophic gastritis, or autoimmune disease (pernicious anemia), and may lead to anemia and, in severe cases, neurological damage.

Symptoms of vitamin B12 deficiency

Low levels of active vitamin B12 can affect several body functions – particularly blood formation and the nervous system. The symptoms often develop gradually and can vary in severity. Here are some common signs that may indicate a B12 deficiency:

  • Fatigue and general weakness
  • Pale skin and shortness of breath
  • Tingling or numbness in hands and feet
  • Dizziness or impaired balance
  • Poor memory, concentration difficulties, and mental fatigue
  • Low mood or depression
  • Sore or inflamed tongue (glossitis) and mouth ulcers
  • Digestive issues such as nausea, loss of appetite, or diarrhea

Tests containing the marker Holotranscobalamin

Vitamin tests

Vitamin tests

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HTC
BLACK WEEKS

S-Holotranscobalamin

Active B12
Marker Icon 1 marker
  • Measures active vitamin B12
  • Detects B12 deficiency earlier than total B12
  • Used in the investigation of anemia, neurological or psychological symptoms
  • Suitable for risk groups such as the elderly, vegans, and people with impaired absorption

    • 279 kr139 kr