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The sample collection fee is a fixed cost that refers to the visit to the clinic where you submit your sample. The fee is not affected by how many tests you have ordered, but varies depending on the order value:

  • For order values under SEK 350, the sampling fee is SEK 129.
  • For order values between SEK 350 and SEK 1000, the fee is SEK 59.
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For purchases over 1000 SEK, the sampling fee is included.

Estrogen and estradiol – what is the difference?

Estrogen and estradiol – what is the difference?

Estrogen is a collective term for several hormones, with estradiol being one of the hormones within the group. Estradiol is the most important estrogen in women of reproductive age.

Quick version

What is estrogen?

Many people think that estrogen is a single hormone, but in reality, it is an entire group of steroid hormones. These hormones play a crucial role in, among other things, the menstrual cycle and fertility, but also in bone density and cardiovascular health. The three most important forms of estrogen are:

  • Estradiol (E2), which is the most potent estrogen in fertile women.
  • Estriol (E3), the hormone that dominates during pregnancy.
  • Estrone (E1), the most common form after menopause.

What is estradiol?

Estradiol is a hormone produced before menopause, primarily in the ovaries. The hormone is central to regulating the menstrual cycle, ovulation, and reproductive health. Estradiol also affects mucous membranes, the skin, bone strength, and emotional well-being.

The difference between estrogen and estradiol

The main difference is that estrogen is an entire hormone family, while estradiol is a specific member of that family – and the most significant during a woman’s fertile years. When people talk about “estrogen deficiency” or “high estrogen levels,” they usually refer to the level of estradiol.

When do estrogen and estradiol vary?

  • Throughout the menstrual cycle: levels rise before ovulation and then drop again before menstruation.
  • Menopause: estradiol production decreases, which can cause typical symptoms such as hot flashes.
  • Pregnancy: estriol becomes dominant, but estradiol also rises significantly.

When and how is estradiol measured?

A blood test can be used to measure estradiol. This may be relevant in fertility problem investigations, suspected menopause and for monitoring ongoing hormone therapy.

Symptoms of altered levels

Changes in estradiol levels can cause various symptoms, including irregular or absent periods, hot flashes and sweating, mood swings, decreased sex drive, and in the long term osteoporosis.

When should you seek medical care?

Seek medical care if you experience:

  • Absence of menstruation for several months without a known cause
  • Sudden and severe menopause symptoms at a younger age
  • Unexplained infertility or long-term difficulty conceiving
  • Signs of osteoporosis or repeated fractures

Treatment and self-care

A healthy lifestyle can support hormone balance. Exercise regularly, eat a balanced diet, and avoid smoking. In cases of severe estrogen deficiency and/or disrupted ovulation, specialized medical care and hormone replacement may be necessary.

Questions and answers

Estradiol is the most active form of estrogen, a female sex hormone. When testing for estrogen in the blood, S-estradiol is most often analyzed, as it is the form that has the greatest impact on the body.

Estradiol is the strongest and most biologically active of all estrogens. Estrone (E1) becomes more prominent after menopause, and estriol (E3) dominates during pregnancy. Together, they contribute to a healthy hormonal balance, but estradiol is the form that influences the most bodily functions during a woman’s fertile years.

When a woman reaches menopause, the production of estradiol drops significantly, which is one of the main causes of typical symptoms such as hot flashes, night sweats, and vaginal dryness. Estrone then becomes the dominant estrogen, but it has a weaker biological effect than estradiol.

Yes, it is possible. During pregnancy, for example, estriol (E3) is the dominant form, and its levels can be high while estradiol levels are lower than normal. This highlights why it is important to distinguish between estrogen as a group and estradiol as an individual hormone.

In hormone therapy, estradiol is most often used because it is the most active and natural form for the body. In some preparations, other forms may also be used, but estradiol is considered to provide the best effect for both symptom relief and long-term health – for example, protection against osteoporosis.

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